Police search house in Lodge …3 females in custody A Guyana Police Force report has detailed that ranks conducting an intelligence-led operation on a house at D’Urban Street, Lodge — on Wednesday, at about 18:30h – have unearthed an unlicensed .32 pistol with 3 rounds and a sub-machine gun with 6 rounds.Three female occupants of the house have been taken into custody, and are assisting with the investigation.
Ray Wilkins has told BBC Radio Manchester he believes Frank Lampard would be accepted by fans and make a major impact were he to join Manchester United.Lampard and Chelsea team-mate Ashley Cole, whose contracts expire this summer, have both been linked with moves to Old Trafford.And Wilkins, who joined United from the Blues in 1979, is convinced Lampard would be a success were he to make the switch.Wilkins said: “He’ll win them [United fans] over because of his footballing ability.“If you look at Old Trafford, if anything they lack goals from the middle of the pitch.“They’ve got goals coming from everywhere else – full-back, centre-half – but from the middle they are not scoring as regularly as when Paul Scholes was a tad younger.“Frank will guarantee you goals because he has that knack of arriving at the right situation and the right time to put the ball in the back of the net, and he finishes like a forward.“Frank has been an unbelievable servant to Chelsea and I honestly felt they would have given him maybe a year or two more.“They have obviously decided to take a different look at the way things are going at Stamford Bridge and alter their philosophy.”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 Follow West London Sport on TwitterFind us on Facebook
Tunnels with rotating gates and rocker switches – this sounds like mechanical engineering. It’s the machinery that helps power your brain, reported scientists from UCLA and the Pasteur Institute. Their paper in Science described the structure of just one of many kinds of membrane channels.1 Cell membranes are lined with elaborate one-way gates. This one binds a sodium ion to a galactose sugar molecule and brings it inside the cell. It’s a key player in the process that brings fuel to the brain. Karpowich and Wang brought it home in their review of the paper in the same issue of Science:2The average Western adult metabolizes hundreds of grams of carbohydrates per day, half of which is used as an energy source for the brain. To benefit from these ingested carbohydrates, they must first be broken down into simple sugars, such as glucose, and absorbed through the epithelial cells of the intestine. The glucose must then be reabsorbed in the kidneys. On page 810 of this issue, Faham et al. report a major advance in elucidating the molecular mechanism by which this highly effective absorption is realized.The wording in this statement reveals the stage that molecular biology is in. Scientists have known about the chemistry of biological processes for decades. Only now, however, are scientists revealing the mechanics behind that chemistry. And mechanics it is: the paper describes gates made of protein that rotate open and closed to let the proper molecules in. Other gates that are members of some of the other 250 families of membrane transporters use other mechanisms. One of them in a simplified illustration in Karpowich and Wang’s review looks like a rocker switch: the cargo drops into a V-shaped mechanism, which when properly authenticated, inverts into an upside-down V and ejects the cargo outside the cell. The sodium galactose transporter studied by Faham et al looks more like a cylindrical gumball machine. As the outside gate rotates, the cargo drops in. Once safely enclosed, the inside gate rotates open and out falls the cargo into the cytoplasm. Faham et al described this an “alternating-access mechanism.” Since they act as one-way gates, Karpowich and Wang called these “symmetric transporters for asymmetric transport.” What did the scientists think of these clever machines? For one thing, the researchers noticed that there are other families of transporters that use similar mechanical methods, but have nothing in common in terms of their protein sequences. “This structural homology is surprising,” they said. “….These findings support classification of proteins using criteria such as topological arrangement, molecular function, and unique structural features involved in mechanism, rather than solely on the basis of primary sequence.” The statement implies that evolutionary relationships are less useful in classifying the machines than functional descriptions. In fact, evolution was never mentioned in either paper. 1. Faham, Watanabe et al, “The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport,” Science, 8 August 2008: Vol. 321. no. 5890, pp. 810-814, DOI: 10.1126/science.1160406.2. Karpowich and Wang, “Symmetric Transporters for Asymmetric Transport,” Science, 8 August 2008: Vol. 321. no. 5890, pp. 781-782, DOI: 10.1126/science.1161495.Riddle: where would Darwinism go if it entered a cell by one of these transporter machines? Answer: first, it would be tagged as foreign and dangerous contraband. Then, a kinesin would carry it down a microtubule to a proteasome, where it would be cut up into little bits, then ejected outside where it belongs. Where would Intelligent Design go? It doesn’t need the transporter, because it’s already in the nucleus, encoded as DNA.(Visited 8 times, 1 visits today)FacebookTwitterPinterestSave分享0
Josh Groban performs at Nelson Mandela’s 90th birthday party concert held in 2008in London. (Image: 46664) My Favorite Place on Earth is written by award-winning travel writer Jerry Camarillo Dunn and published by National Geographic. (Image: National Geographic) A tent at the Wild Dog Research Project camp. (Image: Wild Entrust International) The African Wild Dog is the continent’s most endangered predator. (Image: Wikimedia)Janine ErasmusSouth Africa’s ever-growing desirability as a tourist destination has been further endorsed by superstar singer Josh Groban, who names the country as his favourite place on earth, while National Geographic editor Chris Johns holds similar sentiments for a wild dog research camp in Botswana. This is revealed in a new travel book recently published by National Geographic.The book, titled My Favorite Place on Earth, written by award-winning travel writer Jerry Camarillo Dunn, appeared on shelves on 21 April 2009. In it, Camarillo picks the brains of 75 of the most prominent people of our time, asking them simply, “What is your favourite travel discovery?”Those polled include the likes of film director George Lucas (Monument Valley); comedian Robin Williams (San Francisco); cartoonist Matt Groening (Kauai, Hawaii); tycoon Donald Trump (Palm Beach); couturier Calvin Klein (Maasai country in Tanzania); and travel doyen Arthur Frommer (Ubud in Bali).All took the time to share their experiences and recommendations, describing in detail those unique qualities of their chosen destination that are particularly appealing to them. Their engaging narrative is enhanced by the author’s contribution in the form of interesting National Geographic facts and web links related to each place.“Their choices are fascinating and quirky,” wrote an appreciative Dunn in the book’s foreword. “I sent out hundreds of letters to people I admire,” he added, “explaining the book and asking them to be part of it. Sometimes success was sublimely easy … other times, sublime turned to ridiculous. I called on every friend who had even a sixth-degree of separation from a celebrated person I sought.”Popular singerPopular singer Groban has toured South Africa on a number of occasions, most recently in March 2008, and has built a solid fan base in the country. His albums have topped the charts there, reaching platinum status.During Groban’s first South African tour in 1994 he met former president Nelson Mandela and was inspired to establish his Josh Groban Foundation, which helps disadvantaged children in developing countries with educational and healthcare necessities. Later, the revered elder statesman named Groban as an ambassador of his Aids awareness organisation, 46664.“I had wanted to visit South Africa for many, many years,” said Groban, “and it was life-changing because I made sure to take some extra time off to meet with Nelson Mandela and understand firsthand what his organisation, 46664, is doing for Aids awareness in South Africa.”Since then Groban has collaborated with top local musicians such as Vusi Mahlasela, and Grammy winners Ladysmith Black Mambazo and Dave Matthews, born in Johannesburg but now an international star based in the US.Wild dog fanJohns names the Botswana Wild Dog Research Project, located near the Moremi Game Reserve on the west side of Botswana’s Okavango Delta, as his favourite place of all.Established in 1989 by renowned American wildlife biologist Dr John “Tico” McNutt, the camp is dedicated to the conservation of Africa’s most endangered large carnivore, especially in situations where the creature comes into contact with human communities. McNutt started the project as part of his studies towards his doctorate in animal behaviour, and to date it is the longest-running research facility for large predators in Botswana.In the book, Johns described his meeting with the biologist and his adventures at the Wild Dog Research Project. “The camp has nice double-roofed tents and a community kitchen outdoors. During the day, baboons wander through, and a lot of nights we’d have lions.“My tent folds out on top of my Land Rover,” wrote Johns, “so I sleep up there and some nights I’d hear this BDRRRbdrrbdrr sound, quite loud. I’d wake up, look out through the bug netting in my tent, and be eye to eye with an elephant – literally inches away. Occasionally, elephants would bump the Land Rover and rock it a little bit while I was sleeping. The Okavango is truly a wild place.”EndangeredOne of Africa’s most efficient predators, the African wild dog (Lycaon pictus) is listed as endangered on the Red List of the International Union for Conservation of Nature (IUCN). In terms of IUCN criteria, this means that available evidence points to the species facing a very high risk of extinction in the wild.The animal’s greatest threats are infectious disease such as rabies and distemper, and man, with whom it conflicts because of its tendency to wander far and wide. Research undertaken in Tanzania’s Serengeti indicates that the wild dog’s average roaming area covers some 1 500 km2.Once found in their thousands all over the continent, wild dogs have disappeared from most of their former habitat in west, central and north Africa. Now, significant numbers are found only in southern Africa and the southern part of east Africa.The latest data estimates the current number of free-ranging wild dogs to be no more than 5 500, and the numbers are decreasing.Research at the camp focuses on issues such as habitat and prey species preferences, reproduction patterns, and the health of the population. The success of McNutt’s wild dog research has allowed the programme to evolve to cover other large species predators found in the area, namely the spotted hyena, leopard, lion and cheetah.Now known as the Botswana Predator Conservation Programme (BPCP), the project has three main aims – to use research and education to promote sustainability of Botswana’s large carnivores and their habitats; to contribute to ongoing management programmes and to augment these by developing new techniques that protect threatened carnivores and their habitats; and to educate and mentor the Batswana in appreciating their natural heritage, so that in the future they may become its custodians.“BPCP’s research on wild dogs has made it abundantly clear,” said McNutt, “that the health and welfare of not just the wild dog population but the entire predator population is a key indication of health of the ecosystem. Our project has evolved into an ongoing program of applied research and conservation focusing on the entire large predator guild.”Do you have queries or comments about this article? Contact Janine Erasmus at [email protected] articlesBiggest nature park in the worldSaving the land with ecotourismKruger Park marks 110 yearsUseful linksMy Favorite Place on Earth at National GeographicMy Favorite Place on Earth – websiteWild Entrust InternationalAfrican Wild Dog ConservancyAfrican Wild Dog on IUCN Red ListPainted Dog Conservation Moremi Game ReserveOkavango region
The old oak tree, chained upCaution: The Geocache of the Week may be haunted.Something Sinister … (Staffordshire) (GCNA9Z) is as intriguing as it is scary. Legend has it that a spell was cast on an old oak tree near the cache.According to locals in the West Midlands, UK, a hungry, homeless woman approached Charles, the Earl of Shrewsbury, as he was returning to his castle one winter’s night in 1821. She asked for some money and the Earl angrily rejected her request. She then cursed him and told him that for every branch on the old oak tree that falls, a member of his family will die. The Earl dismissed the curse and carried on his way.That evening a violent storm broke out and a branch fell from the tree. Later the same night a member of the family became ill and mysteriously died. The Earl ordered his servants to chain up the tree so that no more branches would fall. The tree remains chained up to this day.A young geocacher visits the spooky treeThe difficulty 2, terrain 2.5 traditional cache was placed near the tree by MarcB in 2005 and adopted by The Bolas Heathens and Dibbler. The cache and the tree have attracted nearly 400 curious geocachers over the last 7 years.It was the number of Favorite Points that brought the cache to Spanner15‘s attention. After a visit to the spooky location, she awarded it a favorite point and decided to nominate it for the Geocache of the Week.She writes, “Walking through the woods was pretty creepy. As we got closer, you could hear screams, from the tree maybe? When we arrived it was very thrilling and a sight to see. A HUGE tree, draped in chains. Sadly, we left our camera in the car, so we only had a rubbish photo from our phone. However, the memory has remained in my head ever since. The cache was pretty cool – my first ammo can!!! Definitely a favourite point!”Continue to explore some of the most engaging geocaches around the globe. Check out all the Geocaches of the Week on the Latitude 47 blog or view the Bookmark List on Geocaching.com.If you would like to nominate a Geocache of the Week, send an email with your name, comments, the name of the geocache, and the GC code to [email protected] cache container next to the haunted treeShare with your Friends:More SharePrint RelatedKuş Evi / Bird House (GC4W8G4) — Geocache of the WeekDecember 9, 2015In “Geocache of the Week”Zwarte Kaat en de Hellenendse Bende — Geocache of the WeekOctober 23, 2019In “Community”Beach Babe – GCV53Z – GEOCACHE OF THE WEEK – July 30, 2012July 30, 2012In “Community”
Location:FinlandN 65° 05.635 E 028° 54.329 One of the wonderful things about geocaching is how it leads you to locations you may have otherwise never heard of. Case in point: GC1D4ZP.Today’s Geocache of the Week takes us to a remote field in northeastern Finland. As you drive along Highway 5 and look to the east, you will discover an army of over 1000 scarecrows in a field. The peaceful mob is made of wooden crosses, decorated with straw hair and bright clothes, which are refreshed twice a year.The unusual figures are an art installation titled Hiljainen Kansa (“Quiet People” in Finnish) by dancer, choreographer, and artist Reijo Kela. They appeared just north of the town of Suomussalmi in 1994 after exhibiting in three other locations.The trail to the cache can be quite muddy at certain times of the year, so pack your boots or prepare to go barefoot. The description says it’s small, but there’s plenty of room for SWAG and trackables if you have any to trade.Visitors often speak of how walking amongst the figures can be calming and bring about self-reflection. A good thing when thinking about what to write in your log in addition to “TFTC”.Hiljainen Kansa — Silent PeopleView from the roadComing closerThe Quiet PeopleDifferent heights, clothes, and “personalities”Geocachers can blend right inPack your wellies!A birdseye viewA view from the nearby cafe Continue to explore some of the most amazing geocaches around the world.Check out all of the Geocaches of the Week on the Geocaching blog. If you would like to nominate a Geocache of the Week, fill out this form.Share with your Friends:More Difficulty:1.5Terrain:1.5 SharePrint RelatedHaksulandia — Geocache of the WeekJanuary 9, 2019In “Community”RV 5.08 : Brugge — Geocache of the WeekFebruary 13, 2019In “Community””Screaming Skulls” GCPJNV GEOCACHE OF THE WEEK – September 26, 2011September 26, 2011In “Community” TraditionalGC1D4ZPby woltti22